Daniel Waterhouse is summoned to Europe in 1713 in hopes he can calm the dispute between Isaac Newton and scientist/philosopher Gottfried Wilhelm Leibniz, who have independently invented calculus, while adventurer Jack Shaftoe becomes involved with Eliza, an escapee from a Turkish harem on a mission of revenge.

Fifteen-year-old twins Sophie and Josh Newman continue their magical training in Paris with Nicholas Flamel, Scatty, and the Comte de Sant Germaine, pursued by Doctor Dee and the immortal Niccolo Machiavelli.

During a service at a German cathedral, a band of armed intruders disguised as monks gun down the worshippers and clergy and escape with a priceless treasure that could reshape the world.

Fifteen-year-old Josh has chosen to side neither with his twin sister Sophie nor with the Alchemyst, Nicholas Flamel, but rather to fight alongside Dr. John Dee and the mysterious Virginia Dare, while the immortal Machiavelli and Billy the Kid follow the Elders' plans to set loose the monsters of Alcatraz on San Francisco and trigger the end of the humani race.

While working at pleasant but mundane summer jobs in San Francisco, fifteen-year-old twins, Sophie and Josh, suddenly find themselves caught up in the deadly, centuries-old struggle between rival alchemists, Nicholas Flamel and John Dee, over the possession of an ancient and powerful book holding the secret formulas for alchemy and everlasting life.

In the aftermath of a tumultuous event that ripped their world apart, Sydney and her love Adrian need to make their way back to each other, but they must survive first.

While others at St. Bridget's Home for Abandoned Girls dream of adoption, Rose wants only a job and independence until she is hired as maid to Mr. Fountain, an alchemist, and realizes that she, like his grand residence, is filled with magic.

In an effort to rescue her mentor, Nicolas Flamel, centuries-old alchemist Zoe Faust and her best friend, Dorian the gargoyle chef, delve into the world of art forgery to unearth a clue hidden in a stolen painting.

With their romance exposed, Sydney and Adrian face the wrath of the Alchemists and the Moroi alike as Sydney hunts down a former nemesis and Adrian discovers a secret about spirit magic.

"Imagine an Age of Exploration full of alchemy, human dissection, sea monsters, betrayal, torture, religious controversy, and magic. In Europe, the magic is thin, but at the edge of the world, where the stars reach down close to the Earth, wonders abound. This drives the bravest explorers to the alluring Western Ocean. Christopher Sinclair is an alchemist who cares only about one thing: quintessence, a substance he believes will grant magical powers...